Office of the Development Commissioner(MSME), New Delhi, under the Ministry of MSME, formulates the policy governing the Micro, Small & Medium Industries in the country, to chalk out schemes and programmes for development of the MSME Sector. It also monitors the implementation of policies and activities of promotion and development of MSME Sector in the Country through its network of 28 MSME-Development Institutes in all the States, with active involvement of State Directorate of Industries.

MSME-Development Institute, Mumbai was established in the year 1954 as Small Industries Service Institute, Mumbai. In the year 1960, it was shifted to its own premises at Sakinaka, Mumbai. The MSME-DI, Mumbai (erstwhile SISI, Mumbai) Building was inaugurated on 17.04.1960 by Hon'ble Shri S.K.Wankhede, the then Minister of Industry, Govt. of Maharashtra. The Office was headed by its first Director Shri R.V.Patel. The Institute is presently headed by Shri K.R.Sharma, Director. The Directors who headed the Institute are as under :-

This Institute provides support/services to the State Government as well as co-ordinates various activities for the prospective and existing entrepreneurs at the state level for promotion and development of small-scale industries. 23 districts of Maharashtra are under the jurisdiction of this Institute and its Branch Development Institute at Aurangabad.